Clinical characteristics and airway inflammation profile of COPD persistent sputum producers
نویسندگان
چکیده
منابع مشابه
Airway inflammation in COPD: physiological outcome measures and induced sputum.
Chronic obstructive pulmonary disease (COPD) is a result of airway inflammation, and the best predictor of COPD is the early detection of airflow limitation by spirometry. The Global Initiative for Obstructive Lung Disease Workshop Report defines airflow limitation using simple spirometric indices. Available guidelines categorise the severity of COPD using forced expiratory volume in one second...
متن کاملImpact of sputum bacteria on airway inflammation and health status in clinical stable COPD.
Chronic obstructive pulmonary disease (COPD) is characterised by sputum production, bacterial colonisation, neutrophilic bronchial airway inflammation and poor health status. The aim of this study was to determine the impact of sputum potentially pathogenic microorganisms (PPMs) on bronchial airway inflammation, health status and plasma fibrinogen levels in subjects with moderate-to-severe COPD...
متن کاملHeterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8.
STUDY OBJECTIVES To identify the characteristics of airway inflammation in persistent asthma and to examine the role of neutrophilic inflammation in noneosinophilic persistent asthma. METHODS Nonsmoking adults (n = 56) with persistent asthma and healthy control subjects (n = 8) underwent hypertonic saline solution challenge and sputum induction. Selected sputum portions were dispersed with di...
متن کاملClinical applications of assessment of airway inflammation using induced sputum.
Airway diseases account for a significant proportion of the respiratory physician9s workload. Traditionally, conditions are classified according to clinical symptoms and abnormalities of function, although the major categories of airway disease (asthma, chronic cough and chronic obstructive pulmonary disease (COPD)) show considerable overlap in terms of both clinical picture and response to ant...
متن کاملAirway Inflammation in COPD*
Inflammation of the airways has been regarded as a cardinal pathophysiologic feature of asthma for some 20 years. This concept has been based on evidence from a variety of sources: the histologic changes in the airway wall, hyperresponsiveness of the asthmatic airways to a wide range of natural and pharmacologic agents, the presence of activated inflammatory and immune cells and their mediators...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2014
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2014.09.020